Lossless Definition Lossless compression reduces a file's size with no loss of quality. This seemingly magical method of reducing file sizes can be applied to both image and audio files. While JPEGs and MP3s use lossy compression, newer compression algorithms, such as JPEG 2000 and Apple Lossless compression, can be used to create lossless compressed files. Lossless compression basically rewrites the data of the original file in a more efficient way. However, because no quality is lost, ...